White matter abnormalities across different epilepsy syndromes in adults: An ENIGMA-Epilepsy study

SN Hatton; KH Huynh; L Bonilha; E Abela; S Alhusaini; A Altmann; MKM Alvim; AR Balachandra; E Bartolini; B Bender; N Bernasconi; A Bernasconi; B Bernhardt; N Bargallo; B Caldairou; ME Caligiuri; SJA Carr; GL Cavalleri; F Cendes; L Concha; E Davoodi-Bojd; PM Desmond; O Devinsky; CP Doherty; M Domin; JS Duncan; NK Focke; SF Foley; A Gambardella; E Gleichgerrcht; R Guerrini; K Hamandi; A Ishikawa; SS Keller; PV Kochunov; R Kotikalapudi; BAK Kreilkamp; P Kwan; A Labate; S Langner; M Lenge; M Liu; E Lui; P Martin; M Mascalchi; JCV Moreira; ME Morita-Sherman; TJ O'Brien; HR Pardoe; JC Pariente; LF Ribeiro; MP Richardson; CS Rocha; R Rodríguez-Cruces; F Rosenow; M Severino; B Sinclair; H Soltanian-Zadeh; P Striano; PN Taylor; RH Thomas; D Tortora; D Velakoulis; A Vezzani; L Vivash; F von Podewils; SB Vos; B Weber; GP Winston; CL Yasuda; AH Zhu; PM Thompson; CD Whelan; N Jahanshad; SM Sisodiya; CR McDonald

Journal article

White matter abnormalities across different epilepsy syndromes in adults: An ENIGMA-Epilepsy study

SN Hatton, KH Huynh, L Bonilha, E Abela, S Alhusaini, A Altmann, MKM Alvim, AR Balachandra, E Bartolini, B Bender, N Bernasconi, A Bernasconi, B Bernhardt, N Bargallo, B Caldairou, ME Caligiuri, SJA Carr, GL Cavalleri, F Cendes, L Concha Show all

Brain | OXFORD UNIV PRESS | Published : 2020

DOI: 10.1093/brain/awaa200

Abstract

The epilepsies are commonly accompanied by widespread abnormalities in cerebral white matter. ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data to investigate patterns of neuroimaging abnormalities in common epilepsy syndromes, including temporal lobe epilepsy, extratemporal epilepsy, and genetic generalized epilepsy. Our goal was to rank the most robust white matter microstructural differences across and within syndromes in a multicentre sample of adult epilepsy patients. Diffusion-weighted MRI data were analysed from 1069 healthy controls and 1249 patients: temporal lobe epilepsy with hippocampal sclerosis (n = 599), temporal lobe epilepsy with normal MRI (..

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University of Melbourne Researchers

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Patrick Kwan Author

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Heath Pardoe Author

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Funding Acknowledgements

S.N.H: NIH R01NS065838; NIH R21NS107739; L.B: R01 NS110347-01A1; E.A: European Union Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no.75088; S.A: This work was part funded by Science Foundation Ireland (16/RC/3948) and was cofunded under the European Regional Development Fund and by FutureNeuro industry partners; A.A holds an MRC eMedLab Medical Bioinformatics Career Development Fellowship. This work was partly supported by the Medical Research Council [grant number MR/L016311/1]; M.K.M.A: FAPESP 15/17066-0; A.R.B: NIH R01NS065838; B.C.B. acknowledges support from CIHR (FDN-154298), SickKids Foundation (NI17-039), Natural Sciences and Engineering Research Council (NSERC; Discovery-1304413), Azrieli Center for Autism Research of the Montreal Neurological Institute (ACAR), and the Canada Research Chairs program; G.L.C: This work was part funded by Science Foundation Ireland (16/RC/3948) and was cofunded under the European Regional Development Fund and by FutureNeuro industry partners; F.C: The UNICAMP research centre was funded by FAPESP (Sao Paulo Research Foundation); Contract grant number: 2013/07559-3; L.C: Supported by CONACYT (181508 and 1782); and UNAM-DGAPA (IB201712 and IG200117). Imaging was performed at the National Laboratory for magnetic resonance imaging (CONACYT 232676, 251216, and 280283); O.D: Finding A Cure for Epilepsy and Seizures; J.S.D: National Institute of Health Research; N.K.F: DFG FO750/5-1; S.F.F: CUBRIC, Cardiff University; E.G: R01 NS110347-01A1; K.H: Health and Care Research Wales; A.I: Fapesp-BRAINN (2013/07559-3), Fapesp (2015/173350), Fapesp (2016/16355-0); S.S.K: Medical Research Council (MR/S00355X/1 and MR/K023152/1) and Epilepsy Research UK (1085) grants; P.V.K: R01EB015611; B.A.K.K: Epilepsy Action Postgraduate Research Bursary (Research Grants Programme 2014-2015); P.K. is supported by the MRFF Practitioner Fellowship; P.M. was supported by the PATE program (F1315030) of the University of Tubingen; J.C.V.M: FAPESP-BRAINN (2013/07559-3); M.E.M-S: NIH Grant; T.J.O: NHMRC Program Grant (#APP1091593); L.F.R: FAPESP-BRAINN (2013/07559-3); M.P.R: Medical Research Council programme grant (MR/K013998/1); Medical Research Council Centre for Neurodevelopmental Disorders (MR/N026063/1); NIHR Biomedical Research Centre at South London and Maudsely NHS Foundation Trust; C.S.R: FAPESP-BRAINN (07559-3); F.R: CePTERGrant, LOEWE Programme, Minister of Research and Arts, Hesse, Germany; B.S. is supported by Alfred Health, Monash University and Australian Commonwealth grant ICG000723; P.S: This work was developed within the framework of the DINOGMI Department of Excellence of MIUR 2018-2022 (legge 232 del 2016); R.H.S: Epilepsy Research UK; A.V: Epitarget; S.B.V: National Institute for Health Research University College London Hospitals Biomedical Research Centre (NIHR BRC UCLH/UCL High Impact Initiative BW.mn.BRC10269); G.P.W: Medical Research Council (G0802012), National Institute for Health Research University College London Hospitals Biomedical Research Centre, Epilepsy Society; C.L.I.N.Y: FAPESP-BRAINN (2013/07599-3), CNPQ (403726/2016-6); P.M.T. was funded in part by the United States NIH Big Data to Knowledge (BD2K) program under consortium grant U54 EB020403, the ENIGMA World Aging Center (R56 AG058854), and the ENIGMA Sex Differences Initiative (R01 MH116147); N.J: R01MH117601, R01AG059874, R01MH121246, U54EB020403, P41EB015922; S.M. S: The work was partly undertaken at UCLH/UCL, which received a proportion of funding from the Department of Health's NIHR Biomedical Research Centres funding scheme. We are grateful to the Wolfson Trust and the Epilepsy Society for supporting the Epilepsy Society MRI scanner; C.R.M: NIH R01NS065838; NIH R21NS107739.